Vorapaxar sulfate ( —— )

产品货号. M17571 CAS No. 705260-08-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Vorapaxar sulfate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Vorapaxarsulfate 是一种有效的口服活性凝血酶受体 (PAR-1) 拮抗剂。
产品描述

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.(In Vitro):Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
体外实验

Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
体内实验

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同义词

——
通路

Others
靶点

Other Targets
受体

PAR-1
研究领域

——
适应症

——

CAS Number

705260-08-8
分子量

590.66
分子式

C29H35FN2O8S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 125 mg/mL (211.63 mM)
SMILES

S(=O)(=O)(O)O.Fc1cc(c2cnc(/C=C/[C@@H]3[C@H]4[C@@H](C[C@H]5[C@H]3CC[C@@H](NC(=O)OCC)C5)C(=O)O[C@@H]4C)cc2)ccc1
化学全称

——

1. Chackalamannil S, et al. J Med Chem, 2008, 51(11), 3061-3064.

计算器

产品手册

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